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A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 103-111 doi: 10.1007/s11705-021-2064-8

Abstract: Uridine diphosphate (UDP)-glucuronosyltransferases (UGTs) are enzymes involved in the biotransformationwas developed based on boron-dipyrromethene (BODIPY) with high sensitivity for the detection of UGT1A8-dependent fluorescence signal with a good linear relationship with UGT1A8 concentration.In addition, BDMP could also be used to visualize UGT1A8 in tumor tissues.These results suggested that BDMP is a promising molecular tool for the investigation of UGT1A8-mediated

Keywords： UDP-glucuronosyltransferase 1A8     fluorescent probe     subtype selectivity     fluorescence imaging    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: The aim of this study was to explore the regulatory mechanism of retinoic acid (RA) on the TBX1 geneThe expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measuredThere was basal expression of Shh and Fgf8 in the control group.The results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardialAt the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1

Keywords： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 212-218 doi: 10.1007/s11684-016-0438-y

Abstract: Self-complementary adeno-associated virus serotype 8 (scAAV8), a non-human primate AAV featuring lowA strong liver-specific promoter-1 (LP1) was inserted and mutant human FIX Arg338Ala was introduced intoplasmid scAAV8-LP1 to develop an optimized AAV8 vector that expresses human clotting factor FIX (hFIXThe efficiency of scAAV8-LP1-hFIX administered through normal systemic injection or hydrodynamic injectionhydrodynamic injection, and the peak hFIX expression levels in the 5×1011 and 1&

Keywords： hemophilia B     AAV8     hFIX     gene therapy    

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DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 302-312 doi: 10.1007/s11684-021-0851-8

Abstract: DDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrateThe physiological role of DCAF8 is unknown. In this study, we constructed knockout mice.fertility of deficient male mice was markedly impaired, consistent with the high expression of DCAF8The results demonstrated that DCAF8 plays a critical role in spermatogenesis, and DCAF8 is a key component

Keywords： Dcaf8     male infertility     spermatogenesis    

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Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 448-459 doi: 10.1007/s11684-020-0805-6

Abstract: FK506 binding protein 8 (FKBP8) is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptotic(PHB1) specifically interacts with FKBP8.Furthermore, the downregulation of PHB1 inhibited the proliferation of ovarian cancer cells and the mTORin the absence of PHB1.Collectively, our finding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular

Keywords： prohibitin 1     FKBP8     mTOR     cell proliferation     cancer    

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentBoth human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesispathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting theRecently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 221-237 doi: 10.1007/s11705-020-1927-8

Abstract: Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class ofaspects ranging from synthesis methods, property characterization to potential applications of ZIF-8.This review focuses on the recent development of ZIF-8 synthesis methods and its promising applicationsThe potential risks of using ZIF-8 for drug delivery are also summarized.

Keywords： zeolitic imidazolate framework-8 (ZIF-8)     synthesis methods     applications     drug delivery    

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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 388-397 doi: 10.1007/s11684-018-0624-1

Abstract: Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloidHHT) features activity against tumor cells harboring c-KIT mutations, whereas oridonin can induce t(8;HHT increased intracellular oridonin concentration by modulating the expressions of MRP1 and MDR1, thusThe combination of oridonin and HHT prolonged t(8; 21) leukemia mouse survival.indicating that their combination may be an effective therapy for t(8; 21) leukemia.

Keywords： AML1–ETO     c-KIT     homoharringtonine     oridonin     t(8     21) AML     synergistic effect    

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Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

Namita Gupta,N.D. Gupta,Akash Gupta,Saif Khan,Neha Bansal

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 72-76 doi: 10.1007/s11684-014-0347-x

Abstract: This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitisto establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis.Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISAusing Quantikine human total MMP-8 immunoassay kits.The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and

Keywords： matrix metalloproteinase-8     chronic periodontitis     pocket probing depth     clinical attachment level     gingival    

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MoS2/ZIF-8 Hybrid Materials for Environmental Catalysis: Solar-Driven Antibiotic-Degradation Article

Wen-Qian Chen, Linyue Li, Lin Li, Wen-Hui Qiu, Liang Tang, Ling Xu, Kejun Xu, Ming-Hong Wu

Engineering 2019, Volume 5, Issue 4,   Pages 755-767 doi: 10.1016/j.eng.2019.02.003

Abstract: In this paper, we demonstrate a MoS2/ZIF-8 composite photocatalyst that increases the photocatalyticThe hydrogen production rate of the MoS2/ZIF-8 nanocomposites is 1.79 times higher than thatThis work provides a novel perspective for exploring original and efficient 1T/2H-MoS2/MOF-basedThus, 1T/2H-MoS2/MOF-based photocatalysts have excellent prospects for practical antibiotic-degradation

Keywords： 1T/2H-MoS2     ZIF-8     Antibiotic degradation     Photocatalysis    

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Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 188-196 doi: 10.15302/J-FASE-2019253

Abstract: Several studies have indicated that MIC3 and MIC8 are important adhesion factors and potential vaccineBALB/c mice were immunized with rNcMIC3, rNcMIC8, pcDNA3.1-NcMIC3 and pcDNA3.1-NcMIC8 respectively, andThe percentage of IgG1 and IgG2a in the recombinant protein groups was higher than the other groups,and with a predominance of IgG1 over IgG2a, suggesting that recombinant protein vaccines elicited a Th2-type immune response, while DNA vaccines mainly produce a Th1-type immune response.

Keywords： NcMIC3     NcMIC8     Neospora caninum     vaccination    

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The Undersea Tunnel on Qingdao Metro Line 8

Weiguo He, Peng Liu

Engineering 2018, Volume 4, Issue 2,   Pages 167-169 doi: 10.1016/j.eng.2018.03.012

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Development of 8-inch Key Processes for Insulated-Gate Bipolar Transistor Article

Guoyou Liu,Rongjun Ding,Haihui Luo

Engineering 2015, Volume 1, Issue 3,   Pages 361-366 doi: 10.15302/J-ENG-2015043

Abstract:

Based on the construction of the 8-inch fabrication line, advanced process technology of 8-inch wafergreat-leap forward technological development for the manufacturing of high-voltage IGBT from 6-inch to 8-

Keywords： insulated-gate bipolar transistor (IGBT)     high power density     trench gate     8-inch     rail transportation    

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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 909-918 doi: 10.1007/s11684-021-0890-1

Abstract: Results showed that tumor necrosis factor α and interleukin 8 (IL-8) were vital in distinguishing patientsFinally, in-vitro and in-vivo experimental evidence were provided to show that IL-8 influenced

Keywords： acute promyelocytic leukemia     intracranial hemorrhage     cytokines     biomarker    

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IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 403-415 doi: 10.1007/s11684-021-0858-1

Abstract: We have previously shown that interferon regulatory factor-8 (IRF8) and IRF4 serve as tumor suppressorsIn this study, we evaluated the expression of IRF4 and IRF8 and the JAK2V617F mutant allele burden inNegative correlations between the JAK2V617F allele burden and the expression of IRF8 (P <0.05)At 3 months, patients in the CR group showed high IRF4 and IRF8 expression compared with patients inOur data indicate that the expression of IRF4 and IRF8 was associated with the MPN phenotype, which may

Keywords： myeloproliferative neoplasms     IRF4     IRF8     hydroxyurea     essential thrombocythemia    

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Title Author Date Type Operation

A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living

Journal Article

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Journal Article

Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Journal Article

DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren

Journal Article

Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

Journal Article

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Journal Article

Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

Namita Gupta,N.D. Gupta,Akash Gupta,Saif Khan,Neha Bansal

Journal Article

MoS2/ZIF-8 Hybrid Materials for Environmental Catalysis: Solar-Driven Antibiotic-Degradation

Wen-Qian Chen, Linyue Li, Lin Li, Wen-Hui Qiu, Liang Tang, Ling Xu, Kejun Xu, Ming-Hong Wu

Journal Article

Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Journal Article

The Undersea Tunnel on Qingdao Metro Line 8

Weiguo He, Peng Liu

Journal Article

Development of 8-inch Key Processes for Insulated-Gate Bipolar Transistor

Guoyou Liu,Rongjun Ding,Haihui Luo

Journal Article

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Journal Article

IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to

Journal Article